A Peek Into the Possible Future of Management of Articular Cartilage Injuries: Gene Therapy and Scaffolds for Cartilage Repair

Hubert T. Kim, Stefano Zaffagnini, Shuichi Mizuno, Stephen Abelow, Marc R. Safran

DOI: 10.2519/jospt.2006.2284

Two rapidly progressing areas of research will likely contribute to cartilage repair procedures in the foreseeable future: gene therapy and synthetic scaffolds. Gene therapy refers to the transfer of new genetic information to cells that contribute to the cartilage repair process. This approach allows for manipulation of cartilage repair at the cellular and molecular level.

Scaffolds are the core technology for the next generation of autologous cartilage implantation procedures in which synthetic matrices are used in conjunction with chondrocytes. This approach can be improved further using bioreactor technologies to enhance the production of extracellular matrix proteins by chondrocytes seeded onto a scaffold. The resulting ‘‘neo-cartilage implant’’ matures within the bioreactor, and can then be used to fill cartilage defects.

J Orthop Sports Phys Ther. 2006; 36(10):765-773. doi:10.2519/jospt.2006.2284

Key Words: chondral defect, chondrocytes, knee, tissue engineering

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